About... The Liver Support Formulas

HepatoPlex

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Herbal and lipotropic complex for gallbladder/liver support

Product # 9109

120 tablets

tablet

HepatoPlex contains a complex of botanic and nutritional components that support gallbladder and liver function. The compounds in dandelion root, fumitory, barberry root and artichoke leaf extract facilitate bile flow. Betaine and methionine are methyl donors that are required by hepatic detoxification mechanisms. The flavonoids from milk thistle exert a number of useful actions supporting the liver.

• Dandelion, barberry and fumitory are traditional botanical medicines possessing choleretic effects that promote optimal biliary function (Arzneimittelforschung 1959;9:376-8; Med Prom SSSR 1964;18:59-60; Z Allgemeinmed 1971;47:1819-20).
• Artichoke leaf extract has been shown in human clinical studies to have choleretic (bile flow-enhancing) and cholesterol-regulating effects, and also possesses hepatoprotective activity according to in vitro research (Phytomedicine 1997;4:370-8; Wien Med Wochenschr 1999;149:241-7; Arzneimittelforschung 2000;50:260-5).
• Silymarin is a mixture of potent bioflavonoids that support normal repair mechanisms in the liver (Agency Healthcare Res Qual:
  Number 21, September 2000).
• Silymarin contains liver-specific antioxidant properties, directly scavenging free radicals and increasing levels of hepatoprotective glutathione (Tokai J Exp Clin Med 1986;11:121-34).
• Silymarin supports the liver’s resistance to the potentially damaging effects of alcohol, drugs, toxic chemicals, and other substances (Curr Ther Res 1994;S5:S37-45; Z Klin Med 1994;2:22-7).
• DL-methionine protects against hepatotoxicity from xenobiotics such as certain environmental toxins, according to animal research (Toxicol Lett 1981;8:147-52).
• Betaine, a natural methyl donor, reduces the effects of excessive fat storage in the liver (Arzneimittelforschung 2000;50:722-7).

Supplement Facts Serving Size - 2 Tablets Servings per container 60
Amount per serving:		%DV
Fumitory (Fumaria officianalis)*	250 mg	†
Dandelion Root (Taraxacum officinale)*	200 mg	†
Barberry Root (Berberis vulgaris)**	200 mg	†
Artichoke leaf extract (Cynara scolymus)*	200 mg	†
Milk %Thistle (Silybum marianum)***	250 mg	†
D,L-Methionine	200 mg	†
Betaine (citrate complex)	200 mg	†
† Daily Value (DV) not established

Other ingredients: magnesium stearate, stearic acid, silicon dioxide, cellulose, dicalcium phosphate

PLEASE NOTE: We may be shipping an older version of HepatoPlex. Please call our office to find out.

*4:1 concentrate
**3:1 concentrate
***standardized extract providing 80% Silymarin or Silymarin flavonoids

Other ingredients: magnesium stearate, stearic acid, silicon dioxide, cellulose, dicalcium phosphate

Suggested use for adults:

• Two tablets twice daily, away from meals, or as directed.

N-Acetyl-L-Cysteine

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Critical antioxidant and glutathione precursor, with specific support for healthy lung function

Product # 8111

180 capsules

N-Acetyl-Cysteine (NAC) is a precursor of the tripeptide glutathione, a critical antioxidant, with roles in xenobiotic detoxification, amino acid metabolism and immune defense. NAC acts as a mucolytic agent and thus assists normal respiratory function. By acting as a glutathione precursor, NAC helps maintain normal immune, liver and cardiovascular function.

• N-Acetyl-L-Cysteine (NAC) is a precursor of the tripeptide glutathione – a critical antioxidant, with roles in xenobiotic detoxification and amino acid metabolism. Glutathione depletion is characteristic of many conditions of impaired health (Curr Opin Clin Nutr Metab Care 1999;2:487-92).
• N-Acetyl-L-Cysteine (NAC) acts as a mucolytic agent and thus assists in restoring normal respiratory function (Clin Ther 2000; 22:209-21; Respiration 1999;66:495-500; Eur Respir J 1997;10:1535-41).
• By acting as a reliable oral glutathione precursor, NAC helps maintain normal immune, liver and cardiovascular function (Altern Med Rev 1998;3:114-27).

Supplement Facts Serving Size - 2 capsules Servings per container 90
Amount per serving:		%DV
N-Acetyl-L-Cysteine	1000 mg	†
† Daily Value (DV) not established

Other ingredient: rice flour

Suggested use for adults:

• 2 - 6 capsules per day, in divided doses between meals, or as directed.

SAM-e Plus

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Enterically coated tablets with methylation and transulfuration co-factors

Product # 9124

30 tablets

tablets

Product # 9125

60 tablets

tablets

Over a decade of rigorous clinical studies in Europe and elsewhere have established SAM-e (S-adenosyl-L-methionine, an essential methylation and transulfuration cofactor) as a useful tool for supporting normal mood regulation, and joint and liver health. SAM-e increases cell membrane fluidity, up-regulates neurotransmitter receptor number, and enhances neurotransmitter receptor affinity. SAM-e supports healthy joints both by increasing the number of articular chondrocytes, and by stimulating the synthesis of protective sulfated proteoglycans therein. SAM-e also protects synovial cells against pro-inflammatory prostanoids, and blocks enzymes that degrade cartilage. SAM-e is a precursor of the critical antioxidant glutathione, a key molecule in the detoxification process in the liver. SAM-e Plus contains the tosylate form of SAM-e as used extensively in clinical trials, and includes several other ingredients found in studies to support and facilitate these functions. SAM-e Plus tablets are enterically coated, essential for preventing demethylation in the stomach.

• S-Adenosyl-L-Methionine (SAM-e) supports normal liver function by acting as a methyl donor, and by promoting the regeneration of sulfur-containing amino acids and glutathione which protect against oxidative stress and toxic substances (Aliment Pharmacol Ther 1993 Feb;7(1):21-8).
• SAM-e promotes the health of joints by stimulating the synthesis of proteoglycans in articular chondrocytes; SAM-e acts with minimal or no side effects on the gastrointestinal tract and other organs (Am J Med 1987 Nov 20;83(5A):60-5).
• SAM-e is a major source of methyl groups in the brain, and promotes normal brain function in subjects with mood irregularities (Acta Neurol Scand Suppl 1994;154:7-14).
• SAM-e Plus tablets are enterically coated, which is essential since oral SAM-e is largely demethylated in the stomach, thereby losing much of its unique character.
• SAM-e Plus includes additional nutrient factors essential for normal methylation functions (Proc Nutr Soc 1999;58:441-8, Am J Clin Nutr 1995;61:659S-665S).

Supplement Facts Serving Size - 2 tablets* Servings per container 15 or 30
Amount per serving:		%DV
B3 (niacinamid)	30 mg	150%
B6 (pyridoxin HCI )	2 mg	100%
Folic Acid	400 mcg	100%
B12 (cyanocobalamin)	20 mcg	333%
SAM-e (tosylate disulfate)	400 mg	†
Choline (bitartrate)	50 mg	†
† Daily Value (DV) not established

* Enterically coated tablets

Other ingredients: stearic acid, calcium sulfate, AC-DI-SOL, cellulose, vegetable coating

Kept refrigerated prior to shipping for your protection

Suggested use for adults:

• Two to four tablets daily, preferably morning and evening, or as directed.

Sho-Saiko-To

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Traditional Chinese herbal formula for hepatic and immune system support

Product # 5123

60 Capsules

Sho-Saiko-To is the Japanese name for an ancient Chinese formula highly regarded for maintaining healthy liver and immune function. Clinical trials have repeatedly demonstrated the efficacy of this formula for protecting the liver. Adding synergistic benefits to Sho-Saiko-To are the well known western herb Silybum marianum (milk thistle), selenium and vitamin E, all of which have shown hepatoprotective antioxidant activity. The reproduction of certain viruses has been shown in laboratory studies to be inhibited by the ingredients in Sho-Saiko-To.

• Sho-saiko-to, a traditional oriental herbal combination used for liver and immune support, has been the subject of significant scientific scrutiny (J Gastroenterol Hepatol 2000;15:D84-90).
• Sho-saiko-to promotes normal
  serum liver enzyme levels and increases antibodies associated with hepatoprotection (Gastroenterol Jpn 1989;24:715-9).
• In vitro studies indicate that Sho-saiko-to and its constituents inhibit the replication of several viruses (Antiviral Res 1990;14:279-86; Planta Med 1992;58:171-3).
• Sho-saiko-to has been successfully used to reduce the risk of disturbances in normal hepatic chromosomal replication (Jpn J Cancer Chemother 1989;16:1519–24; Cancer 1995;76:743-9). .

Supplement Facts Serving Size - 2 Capsule Servings per container 30
Amount per serving:		%DV
Vitamin E (d-alpha tocopherol)	25 IU	83%
Selenium (selenomethione)	20 mcg	29%
Sho-Saiko-To Extract Formula**	500 mg	†
Yielding:
Yielding the following minimum herbal ingredient percentages in a 10:1 herb extract ratio:
Thoroughwax Root (Bupleurum falcatum)	25%	†
Skullcap Root (Scutellaria baicalensis)	25%	†
Ban xia Rhizome (Pinellia ternata)	10%	†
Ginger Rhizome (Zingiber officinale)	10%	†
Milk Thistle Seed (Silybum marianum)***	10%	†
Jujube Fruit (Zizyphus jujuba)	10%	†
Licorice Rhizome (Glycyrrhiza uralensis)	10%	†
Ginseng Root (Panax)	10%	†
†Daily Value (DV) not established

**Derived in a full spectrum,closed system, low temperature water extraction process.
***Standardized to 20% Silymarin

Suggested use for adults:

• Two capsules daily, taken away from meals or as directed by a health care practitioner

Silymarin

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Potent milk thistle extract for hepatoprotection

Product # 5206

90 Capsules

This flavonoid mixture extracted from milk thistle (Silybum marianum) seeds is referred to as Silymarin and has received some of the most extensive research of any phytomedicinal extract. These flavonoids have a strong affinity for the liver, where they exert a number of useful actions. By acting as antioxidants, increasing intrahepatic glutathione levels and blocking entry of toxins into liver cells, they protect the liver from free radical and other damage. Supporting the liver’s resistance to the harmful effects of alcohol, drugs and other pollutants is another property demonstrated by Silymarin.

• Silymarin is a mixture of potent bioflavonoids that support normal repair mechanisms in the liver (Agency Healthcare Res Qual:
  Number 21, September 2000)..
• Silymarin contains liver-specific antioxidant properties, directly scavenging free radicals and increasing levels of hepatoprotective glutathione (Tokai J Exp Clin Med 1986;11:121-34).
• Silymarin interacts with hepatic cell membranes, thereby blocking binding sites and inhibiting the uptake of toxins such as carbon tetrachloride, alcohol and pollutants (Arzneim-Forsch Drug Res 1980;30:452-4; Toxicol Appl Pharmacol 1979;51:265-75).
• Silymarin supports the liver’s resistance to the potentially damaging effects of alcohol, drugs, toxic chemicals, and other substances (Curr Ther Res 1994;S5:S37-45; Z Klin Med 1994;2:22-7)..

Supplement Facts Serving Size - 1 Capsule Servings per container 90
Amount per serving:		%DV
Milk Thistle (Silybum marianum)*	170 mg	†
† Daily Value (DV) not established

* Standardized extract providing 80% Silymarin or Silymarin flavonoids

Other ingredients: rice flour and silicon dioxide

Suggested use for adults:

• One capsule three times daily, or as directed.